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equa to that os radium and 4ay on the varia celis. The fame may bemaidis quinin in relation to the agenti malaria a was aid bylon Sebastian Recasens of radium.
Biolastica action fradium. - On radiations os radio-active Sub Stances traversin the tiSSues the celis absor these radiations in greater ordeSSer quantity, undergoins cellula modifications in relationto the quantity, notis the ctys traversin them but of the rays absorbed by them. The irs action hic is manifested in cellula lis is the reductionos the geneti power of the celis There occurs, notis much ct alter ation os composition, as an alteratio of the vita function On thecelis radio-active substances always produce, Similarint X raYS, leucocitosis at the besinnins of thei action, it abundance of poly- nuclears. O maintenance of the radio-activeraction howeverra very pronounce leucopenia HypeHrS . The re corpuscle hic lach serminatin propertie doe not, for his reason, underso the actionis quinine.
Experimenta inith infusoria. As a proos of what is sal above I wished to determine hether dehydraled quinin is a the momentis emanationis radio-nctivity. more fata to infusoria than ordinBr quinine. with his objectri carrie out experiment in themateria Medica laboratory directed by the eminent Professor vo ovi, Professoros Therapeutic in the Universit os Bolosna. The infusoria o ha paramecium aurelia examine with stistit magnification in a pendant drop. oni die unde the actionis ordinarysulphat o quinin aster a period whicli varies between five an fif
Quinin in powder a adde to the drop. hereb formin a saturate solution At the besinnins of the experiment the infusoria were Seen to wimietween the crystalsi sulphat o quinine and impelle by positive tactism placed themselves against the crystalSasof the were attracted thei movements were stimulated and finalty
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Dehydrate quinine n contact illi ater ecomes amorphous and assumes a ello colour. his delat is interestin hecause attimes the mali quantit deposited in the dromis rapidi hydraled in contact with the mois surroundin ai and then the infusori do notdieranti the expirno flve to fifteen minutes, jus ascis the case ithordinar sulphate os quinine. The influence of theleat does no operate, because when a fine ii ofincandescent crystalcis immersed in the dromthe infusoria domot die. express m gratitude to the learne Professor Do Novi and tollis assistant. Professor Picinini, both for thei hospitalit an forthe welcome thensave to this modest work. To thei advice and thei mos intelligent directiones am indebled for havin carried out his study.
ula vitalitY, butin the ther han produces the deat of the cell
infusoria than non dehydrate quinine. 5. That it,illae destrabie to sive prope stud to the bellaviouros quinine associale illi radium and X aYs in the reaiment of
BIBLIOGRAPHYRecasens Traiado de Ginecologia.
Schist Arch de sciences phys et nati 1878. Heger Iournal de med. de Bruxelles. 1877. Roger Comptes rendus de la Soc Biol. 1886. Κerner Bettrage ur enniniss de chem Resorption Arch. f. Physiol. Vol II-III. Vincens Tetanos et quinine Buli deri Inst. Pasteur, l907.
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sLE TRAIT EMENT DE LANE MI PALUDE ENNE
Physician to the Paris Hospitala
l adulta the best reaiment for malariat anemia is the systematicinjectio os quinine Very d , or very the d , he theattach are recent: very third o Murthia when there has nothee any attac for ome time. The formula sed in the armY durins the war, an sive to a reat number of soldier o the Salonica
Bi-hydrochloride os quinine . . .. 0.80 ram
Distilled mater . . . . . . . . . . et c. .
The injections must e sive intramuscularly with ver Strictasepti precaution in the lutea reston, it a long needle, andalways bovem horizontal in passin through therappe partis thesluteal furro . Under his line there might be injur to the sciaticnerve, and et it is in this region mostly that injections are made whensivena person other han doctor nurses). The patient is a different an after the thir o Murth injection. The attacks have not recurred the anemia has considerabi decreased, and it completet disappear at the en of the reaiment i 2 intramuscula injections . The treaiment tot followed in severe malariat anemias mill consistia therarst year of two or three series of twelve injections of quinine, and of one or two series in the secon year. his illae the bestprophylacti treaiment for malariat anemia, and the mos favourable technique t master the resistent forms of the parasite. Naturally, as resard the particularly severe forms, it illi a good thin to associale it the bove the symptomati treaiment fanemia Iron preparations sprotoxalate in the dose of 0. 15 ram mor nins and evenins , hemopoleti serum in iis various form per OS PrePHrations of cinctiona bark, etc. The nem araenica commund weremni exceptionalty used before
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the war, an Systematicali durins and after the Salonica expedition. Hoques in his inausura thesis at oulouse l9lli comes to the conclusio that atoW has absolutelymo action Hectine,in the contrHry, sive remarkable resulis it the dos of 0. 10 ora. 20 gram every two or three days the series hein os about 10 injections. Arsenobenzol. Novarsenobenzol, Sullarsenol also sive excellent resulis in malariat anemia. Accorditis to Carnot, it is the ouistandins remedY Givei. 10 fram a the hesinnins and increas by 0. 15 gramat every injection: the maximum doses insi. 50 o 0.60 gramine in
Subculaneous injection are Sometimessainful the seem tote essactive than the intravenous injections These must be preferred without an hesitation. ut O conditio that the Anemi is notrio accentu-ated an also that the renat permeabilityris sood The determinationos the Ambarci constant is indicated before besinnins suci aureaiment,as experience has Shown that the renat complications need tot taken into consideratio in malaria patients.
malaria. Quintne sive intramuscularinis a more powerfui parasiticidethan novarsenobenzol. However the associationis his medicament
illi quinin has a particularly good actioni theilood ascit increases the et count and the hem iobin rate. Besides his Some subjectSwho have attach now and then in Spite o good quinine reaiment, doubilessi greati benefit fro the associationis arseni and quinine. Recently in a patient ho ad contracte malaria in Braetii theset o medicament enable us to obtain an excellent result here quinin alone had been clearly inadequate.
Sodium cacodylate arrhenal, have also an undeniable actioni thesenera condition and o the blood, in malariat anemia. certain amount of data concerning the good effect of splenec tom in malaria cachexia, and nemia illi plenomegalia, AS
patient illi malaria an an enlarsed pleen, illi AcheXia, and Severe functiona troubles must be operate on. It is certain that when his interventio is successia it determine the disappearanceo abdominatisains improves the genera condition ameliorate thectnemia, and does way with such danserous complications AS rupture of the spleen torsio of the pedicte abceSSes, infarction.
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The objectio ma be alsed that deSpite the Splenectomy, malaria
is no cured that the operationes a Severe ne, Scit has a mortality
o such an operation ill thereiore ni he considered after complete fallure of the medicat reaiment. Splenectom sive a hisher deathrate than exosplenorex incent' operation . the effect of whichare les rapid. ut whicli has the advantas of AVoidin an serious risks to the patient. Besides, in the caseis irreducibi malaria splen- omegalia it wouldie good before attemptin the extirpatio of the spleen to Se radium applications as uenu and Deserata did success-
In infanta the best,anto stopuli progressis destobulisation andenabi the rectificationis biood disturbances, is to make intramuscularinjections of 5 lsr o quinine formiate very ay, and later eve other day A series of 8 to 10 injections is senerali enovsh to stopali rise of temperatur an to ho an improvement of the anemia, without havin to se at the fame time the iron medication It willhoweve be preferable later on to sive ome iron protoxalate 0.20 gram per day for ten days, nce or severa times, sorus to enabi theorganismo reconstitute it iron reserves hicli, indie a a so
attach, the anemia has a tendencyloreappear, oris the Spleen increaseSin volume, a ne series of 6 ora injections o quinine formiate millhe siven, ne injectio every thir o Murth day. Quinoforme Lacroix, hecause of iis excellent preparatio an iis perfeci conservation, ill render rea service to adult as et a tochildren.
change of climate and speciali the ojourn of malaria patientsin a temperate climate like that o France is excellent at ali ases Aminerat sprinincur is the more indicate formalariat anemia becauseth hematopoleti orsans, live and kidney, are uti order. The associatio of histi altitude climate and arsenic reaiment laBourboule fave Boudr remarhable resulis. Heiotice that aster a monili 's reaiment the hemoslobin rate increased roma or lyto lior 2: ut speciali that the proliferation o re corpuscle is o intens that a retur of the numbe to the norma is the usual thing. Malaria anemic mill ver much benefit Domin irst cure at Vichy, follo edi a sta in a climati reSort.
Lombar o Geneva, quote by Mauret thinks that a medium latitude 3300 t. is advisable forinemi conditions due t frequent
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130 HE REAT MENT OF MALARIA AN EMIA
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PALUDISME AU COURS DE LA GROSSESSE TRAITE PAR DESDOSES MASSIVE DE QUININEi
Professor of the School o Medicine a Dahar, Mnesal
Examinedin the 20t Februar 1922 at Dahar Medium stouinessan stature. Mel bulli genera conditio good no syphiliti Sign. There is a light presystoli murmur due o mitra stenonis, butthere is no sis of heari strain. Urine normal, Spleen and live normal. She is found to e two month advance in pregnancy, hich Stakin iis normat course aster a miscarriase due perhap to malaria. we advise 0 50 ram quinine every day instead of the usuali 25 gram. 24t Ianuary 924. Calle to the patient urgenti atralis.m. e find a typical attack of paludism,ith a temperatur of q0-2 C. The patient complains of somesain in the abdomen and ear a miscarriase. No asina discharse. e supervis immediate administrationi 2sram os sulphate os quinin in cacheis of 0.50 gram each. 25ti February. About 8 in the morning one gramis Sulphate of
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26th February No more laver The eliminationis urine satisfactory. One ramo sulphat o quinin internali mornins and evenins.
asent in question a the parasite os tropica laver the plasmodium praecox. Some re globules containe two and three parasites. From therarci Marchin ards one gramis quinin in t o portionS
R. . . A Frenchwoman o 23 years of age, arrive in Senesa in Augustra 912 for her first sta in the colonies. During the firs se
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hadiain in the lower abdomen, correspondin to the uterine oneand kidneys. No vagina discliarse. Urine contain no albumen ali
we advis quinin administere intramuscularly, ut the patient refuses havins heard of the abscesses hic somelimes follow injectionso quinine. e then rescribe complete est, enem conininins laudanum and 2 gram os hydrochlorate os quinin tot taken in cacheis of 0. 25iram each very two hourS.Itb October Feverisii nistit vomitin once. At 94.m. 39.39. C. pains in abdomen continue, ithout asina dis harse. e strongi insist in favour os a more energetic rectiment eSpeciali as Dominilood film aken the da be re, e find the existenceo numerous hematoetoa, of the formis plasmodium praecox. The patient agrees o injections o quinine an receives in the ourse of
At 94.m. 1 gram o hydrochlorate os quinin intramuscularly. At 2 p.m liram os hydrochlorate os quinin internalty inqcacheis. At 6 p.m. 14ram os hydrochlorate os quinin intramuScularly.
In Ghours his ouns oman. bout four monilis advance in pregnancy, has thereiare received iram os quinine two fram hyintramuscula injectio and three gram internalty.8t October a belle nisiit temperature 37-5'. C. Common Sisnso cinctionism tinnitus, muscae volitantes and stistit rednessin chest.
drochlorate os quinin inra cacheis. 9th October Temperature 38'. C. Wo gram o hydrochlorateo quinin intramusculari a lya.m. n 6 P.m.l0t October Temperature 37 3 Q. ne fram o hydrochlorateo quinin in cacheis. Hili October. Temperature 36 8 Q. Same rectiment. l2tb October Temperatur 36 7 Q, iram o hydrochlorateo quinin in two intramuscula injectionS.
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absence of hematoetoa, there remo more pigmenta granulations in the mononuclea leucocyteS.
From 23r October o 23rci November liram os quinine per daY.Toward the end of October active movement an heari Soundso foetus perceptible. we advis the patient to take every da from the 23r Novemberto the 23r December -7biram o hydrochlorate os quinin in cataeis and after that, every day, a long as he continues o live in Senegat. 0 50iram o hydrochlorate os quinin ina cacheis.
the ther Mur monilis advanced in pregnancy, attacked with paludismand threatene mitti miscarriase, and who, on ein treate with quinin in very large doses, id no miscarry the pregnan runninsita normat course and the childrenaeinsior alive and weli Theyabsorbed both internali and by intramuscula injections 164ramso quinin in 7 days andra fram os quinin in 17 days respectively. These two facts spea in favour of the harmiessnes of quinine durins presnancy. The even usses that the fac that a miscarriase asprevented is due to this intensive reaiment.